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P4-P6 Structure

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Crystal structure of the P4-P6 domain of the Tetrahymena self-splicing intron. Helices on the right side of the molecule fold around a magnesium ion core (not shown) and dock into the helices of the catalytic core at left. The 2.8-Å structure provides a detailed view of many RNA folding motifs.

References:

Cate, J.H., Gooding, A., Podell, E., Zhou, K., Golden, B., Kundrot, C., Cech, T.R. and Doudna, J.A. (1996) Crystal structure of a group I ribozyme domain: Principles of RNA packing. Science 273, 1678-85. (360KB PDF)

Cate, J.H., Gooding, A., Podell, E., Zhou, K., Golden, B., Szewczak, A., Kundrot, C., Cech, T.R. and Doudna, J.A. (1996) RNA tertiary structure mediation by adenosine platforms. Science 273, 1696-99. (156KB PDF)

© 1996 American Association for the Advancement of Science

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