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Click on the image to view a full-sized version of the dicer structure (1.5MB).
Crystal structure of Giardia Dicer.
- Front and side view ribbon representations of Dicer showing the
N-terminal platform domain (blue), the PAZ domain (orange), the
connector helix (red), the RNase IIIa domain (yellow), the RNase IIIb
domain (green) and the RNase-bridging domain (gray). Disordered loops
are drawn as dotted lines.
- Close-up view of the Dicer catalytic sites; conserved acidic
residues (sticks); erbium metal ions (purple); and erbium anomalous
difference electron density map, contoured at 20s (blue wire mesh).
Dashed lines indicate distances described in the text.
Reference:
MacRae, I.J., Zhou, K., Li, F., Repic, A., Brooks, A.N., Cande,
W.Z., Adams, P.D., and Doudna, J.A. (2006)
Structural basis for double-stranded RNA processing by Dicer.
Science 311, 195-198.
(288KB .pdf)
(Structure)
© 2006 The American Association for the Advancement of Science
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