Click on the image to see the
full-size view.
|
|
Model for HCV IRES-coordinated assembly of human translation
initiation complexes. 40S subunit binding to IRES RNA with
an intact IIId loop is required for IRES-40S association;
eIF3 interaction with the IIIb region of the IRES is required
for stable association of eIF3 and eIF2 in the 48S complex,
whereas eIF3 contacts to the junction of stems IIIa, -b
and -c, as well as the 40S conformational change induced
by DomII, are necessary for downstream events required for
60S subunit joining.
Reference:
Ji, H., Fraser, C.S., Yu, Y., Leary, J. and Doudna, J.A. (2004)
Coordinated assembly of human translation initiation complexes by the
hepatitis C virus internal ribosome entry site RNA.
PNAS 101, 16990-16995.
(508KB PDF)
© 2004 The National Academy of Sciences of the USA
..: Back :..
|
