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Click on the image to view a movie of the conformational change (1.36MB).
(Download QuickTime)
- Cryo-electron microscopy (cryo-EM) of 40S ribosomal subunit at ~20-Å resolution.
- Cryo-EM reconstruction of a complex between the 40S ribosomal subunit
(yellow) and the internal ribosome entry site (IRES) RNA of hepatitis
C virus (purple). Comparison with the structure in Figure A reveals
a conformational change in the 40S subunit (upper right) induced by
IRES binding.
- Representative RNA helices fit the dimensions of the IRES RNA density.
Reference:
Spahn, C.M.T., Kieft, J.S., Grassucci, R.A., Penczek, P., Zhou, K.,
Doudna, J.A. and Frank, J. (2001) Hepatitis C virus IRES RNA-induced
changes in the conformation of the 40S ribosomal subunit. Science 291, 1959-1962.
(348KB PDF)
© 2001 The American Association for the Advancement of Science
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