The Doudna Lab

Exploring molecular mechanisms of RNA-mediated gene regulation

Collecting X-ray diffraction data at the Advanced Light Source Ancestral cGAS homologs reveal evolution of innate immune signaling Operating the ITC in our lab in Stanley Hall Macromolecular crystallography facilitated by robotics at UC Berkeley Analyzing RNA samples using gel electrophoresis in the lab

Recent publications

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.

Oh S, Flynn RA, Floor SN, Purzner J, Martin L, Do BT, Schubert S, Vaka D, Morrissy S, Li Y, Kool M, Hovestadt V, Jones DT, Northcott PA, Risch T, Warnatz HJ, Yaspo ML, Adams CM, Leib RD, Breese M, Marra MA, Malkin D, Lichter P, Doudna JA, Pfister SM, Taylor MD, Chang HY, Cho YJ.
Oncotarget 2016 Apr 5

A bacterial Argonaute with noncanonical guide RNA specificity.

Kaya E, Doxzen KW, Knoll KR, Wilson RC, Strutt SC, Kranzusch PJ, Doudna JA.
Proc Natl Acad Sci U S A 2016 Mar 30

Programmable RNA Tracking in Live Cells with CRISPR/Cas9.

Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna JA, Yeo GW.
Cell 2016 Mar 16

Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering.

Nuñez JK, Harrington LB, Doudna JA.
ACS Chem Biol 2016 Feb 9

Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.

Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA
Science 2016 Jan 14. pii: aad8282.

Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering.

Wright AV, Nuñez JK, Doudna JA
Cell 2016 Jan 14;164(1-2):29-44.

News

Janice Chen and Lucas Harrington pass their quals! Congrats!!


Yun Bai leaves for her new faculty position at ShanghaiTech, congrats Yun!


Jennifer Doudna was on the PBS NewsHour


Steve Lin leaves for his new faculty position at Academica Sinica, congrats Steve!


Jorge passes his quals!


Photos and presentations from the NAM Human Gene-Editing Initiative