The Doudna Lab | RNA biology at UC Berkeley, HHMI

Operating the ITC in our lab in Stanley Hall

Macromolecular crystallography facilitated by robotics at UC Berkeley

Collecting X-ray diffraction data at the Advanced Light Source

Analyzing RNA samples using gel electrophoresis in the lab

Bacterial immunity

In bacteria, CRISPR systems preserve invading genetic material and incorporate it into surveillance complexes to achieve adaptive immunity. Cryo-EM structure of the CASCADE complex solved in collaboration with the Nogales Lab.
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RNA interference

Eukaryotes use a system known as RNA interference, or RNAi, to process host and viral nucleic acid into small interfering RNA (siRNA) or micro-RNA (miRNA) complexes, which then control gene expression. Work in the Doudna lab focuses on miRNA processing.
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Translational Control

The eukaryotic translation machinery is a critical control point for the induction of gene expression. Viruses by necessity hijack the translational equipment. Pictured is the HCV IRES which bypasses normal regulatory mechanisms to promote viral gene expression.
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Recent publications