The Doudna Lab

Exploring molecular mechanisms of RNA-mediated gene regulation

Collecting X-ray diffraction data at the Advanced Light Source Ancestral cGAS homologs reveal evolution of innate immune signaling Operating the ITC in our lab in Stanley Hall Macromolecular crystallography facilitated by robotics at UC Berkeley Analyzing RNA samples using gel electrophoresis in the lab

Recent publications

Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response.

Heler R, Wright AV, Vucelja M, Bikard D, Doudna JA, Marraffini LA.
Mol Cell. 2017 Jan 5;65(1):168-175. doi: 10.1016/j.molcel.2016.11.031. Epub 2016 Dec 22.

Cornerstones of CRISPR-Cas in drug discovery and therapy.

Fellmann C, Gowen BG, Lin PC, Doudna JA, Corn JE.
Nat Rev Drug Discov. 2016 Dec 23. doi: 10.1038/nrd.2016.238. [Epub ahead of print]

New CRISPR-Cas systems from uncultivated microbes.

SBurstein D, Harrington LB, Strutt SC, Probst AJ, Anantharaman K, Thomas BC, Doudna JA, Banfield JF.
Nature. 2016 Dec 22. doi: 10.1038/nature21059. [Epub ahead of print]

RNA scanning of a molecular machine with a built-in ruler.

Koh HR, Kidwell MA, Doudna JA, Myong S.
J Am Chem Soc. 2016 Dec 13. [Epub ahead of print]

ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing.

Chen X, Shen Y, Draper W, Buenrostro JD, Litzenburger U, Cho SW, Satpathy AT, Carter AC, Ghosh RP, East-Seletsky A, Doudna JA, Greenleaf WJ, Liphardt JT, Chang HY.
Nat Methods. 2016 Oct 17. doi: 10.1038/nmeth.4031. [Epub ahead of print]

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells.

Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ, Marson A.
Cell Rep. 2016 Oct 25;17(5):1438-1452. doi: 10.1016/j.celrep.2016.09.080.

News

Congratulations to lab alumni Blake Wiedenheft who has just been selected for the Presidential Early Career Awards for Scientists and Engineers (PECASE). Read more about this impressive accomplishment. Congratulations Blake!


Save the Date: January 26th at 7pm George Church will be speaking about the science of CRISPR in the International House at UC Berkeley. The event will be open to the public and, due to space limitations, we will require advance registration. Details for how to register will be available on the IGI Website Friday January 13th. In the meantime, please hold the evening on your calendars as it is sure to be a popular and fascinating talk.


Best wishes to Ireen who heads back to Germany to complete her studies at the Technical University of Darmstadt.


Welcome visiting scholars: Michael Schmitz and Eelco Meerdink come to work in the Doudna Lab!


Welcome new postdocs! April Pawluk, Chun-Hao Huang, Gavin Knott, Junjie Liu and Kyle Watters join the Doudna Lab!


David leaves to be a Research Fellow at University of Texas, Austin. Congratulations!


Jennifer Doudna is awarded the 2016 Tang Prize in Biopharmaeutical Science